In fact, Burmese cats are the same as other animals, they will get sick, and there are some genetic diseases in their bodies. Hypertrophic heart disease is one of the common genetic diseases in Burmese cats, so do you know what its etiology and symptoms are? Let’s take a look with the editor.

Burmese

Introduction to Hypertrophic Heart Disease

Myocardiac hypertrophy (HCM) is an adaptive response of the heart to hemodynamic overload. It includes the increase of myocardial protein synthesis, the increase of volume and the proliferation of myocardial fibroblasts, which was unified as hypertrophic cardiomyopathy in 1979. Regarding hypertrophic heart disease in animals, it has been reported for a long time that posterior aortic embolism, one of the main symptoms of feline cardiomyopathy, has been reported. It has been reported in detail as early as 1930 to 1966. The main lesions are myocardial hypertrophy, the left ventricular cavity becomes smaller, the ventricular wall becomes hard, and the myocardial elasticity is reduced. Therefore, cardiac hypertrophy in cats is more common in clinical practice.

Cardiac hypertrophy is a basic adaptive response of the heart to acute and chronic hemodynamic overload. Cardiac hypertrophy phenotypic characteristics are determined by intranuclear gene expression patterns. The gene expression patterns induced by different stimuli depend mainly on the signal transduction pathways they initiate. The most likely breeds are cats, small dogs such as Beijing Ba, Pomeranian, etc.

Myocardial hypertrophy is not a physiological, benign, adaptive compensatory process, but a pathological process that can seriously damage cardiac function. The pathogenesis of cardiac remodeling and ventricular hypertrophy is multifaceted, among which local and circulating neuroendocrine factors may play a greater role. Hypertrophic cardiomyopathy is characterized by asymmetric hypertrophy of the ventricular septum, abnormal hypertrophy of cardiomyocytes, disordered alignment, and forward movement of the mitral valve during systole. A hypertrophic heart wall reduces compliance, resulting in increased ventricular filling resistance.

Hypertrophic Heart Disease Symptoms

Cats may not have any symptoms early on, but as the disease progresses, symptoms of heart failure, and/or Thromboembolism, or sudden death, acute onset of dyspnea and lethargy, anorexia, depression, inactivity, and reluctance to move. Clinical symptoms may include any of the following: decreased activity (drowsiness), dyspnea (dyspnea), shortness of breath (tachypnea), decreased or no appetite (anorexia), vomiting, posture (reluctance to lie down, front wide legs posture), syncope (fainting) and sudden death. Thromboembolism may cause sudden hindlimb paralysis and constant screaming in pain. Typical 5P symptoms: pain and even howling (Pain), paresis (Paresis), pale mucous membranes (Pallor), hind limb paralysis without pulse (Pulselessness), body temperature floating (Poikilothermy), and even sudden death due to cardiac rhythm disorders. We don't want a cat to recognize cardiomyopathy after sudden hindlimb paralysis or death.

Cardiomyopathy is a disease that may occur in all cats. At present, it is believed that the etiology of cardiomyopathy is unknown in most cases. However, some factors such as viral diseases and genetic mutations are suspected to have the potential to cause disease. Male cats seem to be more common. In humans, most hypertrophic cardiomyopathy is caused by genetic mutations; more than 120 different genetic mutations have been identified. There are statistical reports showing that British Shorthair, American Shorthair, Exotic Shorthair, Scottish Fold, Norwegian forest cats, ocelots, Persians are genetically predisposed, but Maine Coons and ragdolls >The presence of a mutated gene that causes hypertrophic cardiomyopathy has been identified, and cardiomyopathy can be diagnosed by genetic testing.

Comments

This disorder, which is not detected at birth, is a progressive disorder. Some cats die as kittens, but most commonly cats live years without symptoms. If a veterinarian with experience and knowledge in the field, with good equipment, uses an ultrasound examination, in most cases, though not always, a cat can be diagnosed by the age of three years. , but some sick cats can live for a long time. Asymptomatic cats often die suddenly from severe cardiac arrhythmias, or are only known to have the disease due to blood clots in their hind legs. Cats can also develop cardiac insufficiency. Symptoms can be relieved with medication, but there is no cure.